It's the Israel Levin Senior Adult Center –
This senior citizen center played a prominent role in Lynne Littman's 1976 Oscar-winning short "Number Our Days" and Jeremy Kagan's "The Big Fix" (1978) where private detective Moses Wine (Richard Dreyfuss) visits his radical communist aunt; its mural "Chagall Comes Back to Venice Beach" can be seen in "Falling Down" (1993), with Michael Douglas and Barbara Hershey.
The mural is "Chagall Returns to Venice Beach" – 201 Ocean Front Walk (between Ozone and Rose Avenue) by Christina Schlesinger. This is the 1996 reconstruction of and elaboration on the original mural from 1991 that was destroyed in the 1994 Northridge earthquake.
It's rather famous, and at LA Murals you'll find an explanation of its imagery – most of it comes directly from the work of Russian-Jewish painter Marc Chagall, but dropped into the setting of Venice Beach. Why not?